Selective modulation of cell surface proteins during vaccinia infection: A resource for identifying viral immune evasion strategies

Journal article

(A) Peptide ratios comparing the peptide count for a given protein in the PMP vs. WCL [9] for all human proteins quantified in both PMP replicates. ‘PMP only’ = not detected in any of the WCL replicates. ‘PM annotation’ includes GO terms PM, CS, XC and ShG. (B) Cut-off peptide ratio of 0.5 (dashed line), as determined in panel A, applied to 73 VACV proteins detected in either of the PMP replicates to identify high-confidence VACV PM proteins (Table 1). (C) Temporal profiles of all known and high-confidence VACV PM and secreted proteins. Data are represented as mean ± SD (PMP n = 2; WCL n = 3, A43: WCL n = 1).

Authors: Depierreux, DM; Altenburg, AF; Soday, L; Fletcher-Etherington, A; Antrobus, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS Pathogens
• Volume: 18
• Issue: 6
• Pages: e1010612-e1010612
• Publication date: 2022-06-21
• DOI: 10.1371/journal.ppat.1010612
• EISSN: 1553-7374
• ISSN: 1553-7366
• Language: English
• Keywords: Virus; Downregulation and upregulation; Cell biology; Virology; Biology; Immunity; Immunology; Oncolytic virus; Immune system; Gene; Vaccinia