Journal article
Cytotoxicity of tranexamic acid to tendon and bone in vitro: Is there a safe dosage?
- Abstract:
- Topical TXA treatment demonstrated dose- and time-dependent cytotoxicity to tendon-derived cells and osteoblast-like cells with concentrations 20 mg/ml and above in isolated 2D and 3D in vitro culture. On the basis of these findings, concentrations of less than 20 mg/ml are expected to be safe. Orthopaedic surgeons should show caution when considering topical TXA treatments, particularly in soft tissue and un-cemented arthroplasty procedures.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1186/s13018-022-03167-5
Authors
+ Maurice and Phyllis Paykel Trust
More from this funder
- Funder identifier:
- 10.13039/501100001518
- Grant:
- 193119
- Publisher:
- BioMed Central
- Journal:
- Journal of Orthopaedic Surgery and Research More from this journal
- Volume:
- 17
- Issue:
- 1
- Pages:
- 273-273
- Article number:
- 273
- Publication date:
- 2022-05-15
- DOI:
- EISSN:
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1749-799X
- ISSN:
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1749-799X
- Language:
-
English
- Keywords:
- Pubs id:
-
1268330
- Local pid:
-
pubs:1268330
- Source identifiers:
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W4280543929
- Deposit date:
-
2026-04-27
- ARK identifier:
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Terms of use
- Copyright date:
- 2022
- Licence:
- CC Attribution (CC BY)
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