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Active forces in confluent cell monolayers

Abstract:

We use a computational phase-field model together with analytical analysis to study how intercellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. We explore the regime where intercellular forces dominate the tissue dynamics, and polar forces are negligible. Contractile intercellular interactions lead to cell elongation, nematic ordering, and active turbulence characterized by motile topological defects. Extensile interactions resul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1103/PhysRevLett.130.038202

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0001-8268-5469
Publisher:
American Physical Society
Journal:
Physical Review Letters More from this journal
Volume:
130
Issue:
3
Article number:
038202
Publication date:
2023-01-20
Acceptance date:
2022-12-22
DOI:
EISSN:
1079-7114
ISSN:
0031-9007
Pmid:
36763395
Language:
English
Keywords:
Pubs id:
1328346
Local pid:
pubs:1328346
Deposit date:
2023-03-18

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