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Microevolution of Burkholderia pseudomallei during an acute infection.

Abstract:
We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.
Publication status:
Published

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Publisher copy:
10.1128/jcm.01219-14

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Holden, MT More by this author
Coupland, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Publisher:
American Society for Microbiology
Journal:
Journal of clinical microbiology
Volume:
52
Issue:
9
Pages:
3418-3421
Publication date:
2014-09-05
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
URN:
uuid:2c70e0d3-8a17-4be4-b2ee-8f3f71776e3d
Source identifiers:
471160
Local pid:
pubs:471160
Language:
English

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