- Abstract:
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BACKGROUND: RTS,S is the most advanced candidate malaria vaccine but it is only partially protective and the causes of inter-individual variation in efficacy are poorly understood. Here, we investigated whether peripheral blood monocyte-to-lymphocyte ratios (ML ratio), previously shown to correlate with clinical malaria risk, could account for differences in RTS,S efficacy among phase II trial participants in Africa. METHODS: Of 11 geographical sites where RTS,S has been evaluated, pre-vaccin...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
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(tiff, 73.2KB)
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(doc, 275.5KB)
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(pdf, 353.1KB)
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- Publisher copy:
- 10.1186/1741-7015-11-184
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- Publisher:
- BioMed Central Ltd. Publisher's website
- Journal:
- BMC medicine Journal website
- Volume:
- 11
- Issue:
- 1
- Pages:
- 184
- Publication date:
- 2013-01-01
- DOI:
- EISSN:
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1741-7015
- ISSN:
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1741-7015
- URN:
-
uuid:2c6ac8d7-31f6-4b78-8d4c-4f7f4b593474
- Source identifiers:
-
418596
- Local pid:
- pubs:418596
- Copyright holder:
- Warimwe et al.
- Copyright date:
- 2013
- Notes:
- © 2013 Warimwe et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data.
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Funding
PATH Malaria Vaccine Initiative
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GlaxoSmithKline Biologicals s.a.
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