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Journal article

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data.

Abstract:

BACKGROUND: RTS,S is the most advanced candidate malaria vaccine but it is only partially protective and the causes of inter-individual variation in efficacy are poorly understood. Here, we investigated whether peripheral blood monocyte-to-lymphocyte ratios (ML ratio), previously shown to correlate with clinical malaria risk, could account for differences in RTS,S efficacy among phase II trial participants in Africa. METHODS: Of 11 geographical sites where RTS,S has been evaluated, pre-vaccin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1741-7015-11-184

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
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More from this funder
Funding agency for:
Warimwe, GM
PATH Malaria Vaccine Initiative More from this funder
GlaxoSmithKline Biologicals s.a. More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC medicine Journal website
Volume:
11
Issue:
1
Pages:
184
Publication date:
2013-01-01
DOI:
EISSN:
1741-7015
ISSN:
1741-7015
URN:
uuid:2c6ac8d7-31f6-4b78-8d4c-4f7f4b593474
Source identifiers:
418596
Local pid:
pubs:418596

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