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Yeast artificial chromosomes: an alternative approach to the molecular analysis of mouse developmental mutations.

Abstract:

Mammalian genetics now allows a molecular study of genomic regions previously analysed by genetic and embryological techniques. To simplify such an analysis, we have established a number of libraries of mouse DNA in Yeast Artificial Chromosome (YAC) vectors, constructed either by partial digestion with EcoRI, or by complete digestion with enzymes which cut rarely in the mammalian genome. In this paper we report the construction of complete digest libraries prepared from mouse genomic DNA usin...

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Publication status:
Published

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Publisher copy:
10.1017/s0016672300035308

Authors


Journal:
Genetical research
Volume:
56
Issue:
2-3
Pages:
203-208
Publication date:
1990-01-01
DOI:
EISSN:
1469-5073
ISSN:
0016-6723
URN:
uuid:2c69a87d-da81-4bf9-b88c-9abe66f9aa09
Source identifiers:
53537
Local pid:
pubs:53537

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