Colonic mucosal -synuclein lacks specificity as a biomarker for Parkinson disease

Journal article

Editors' Note: Commenting on the lack of specificity of colonic mucosal α-synuclein as a potential biomarker in Parkinson disease, Ruffmann and Parkkinen share their “Discovery study” findings, which in part agree with the work of Visanji et al. and in part raise additional questions. Furthermore, Woulfe et al. have inquiries regarding the neuropathology technique and interpretation. Visanji et al., authors of the study, provide answers and potential explanations.—Chafic Karam, MD, and Robert C. Griggs, MD

Authors: Ruffmann, C; Parkkinen, L; Woulfe, J; Gray, M; Munoz, D

• Publication status: Published
• Publisher: American Academy of Neurology
• Journal: Neurology
• Volume: 85
• Issue: 9
• Pages: 834-835
• Publication date: 2015-09-01
• DOI: 10.1212/WNL.0000000000001904
• EISSN: 1526-632X
• ISSN: 0028-3878