Sperm selection for assisted reproduction by prior hyaluronan binding: the HABSelect RCT

Journal article

Background: Sperm selection for intracytoplasmic sperm injection (ICSI) has traditionally relied on standardised methods of sperm processing combined with subjective sperm selection (motility/morphology). In 2012, live birth rates (LBRs) stood at ≈24% per cycle started (32% per cycle reaching embryo transfer). Objective(s): The main clinical objective was to determine the benefits of a hyaluronan (HA)-based sperm selection process for physiological intracytoplasmic sperm injection (PICSI)....

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Authors: Kirkman-Brown, J; Pavitt, S; Khalaf, Y; Lewis, S; Hooper, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: NIHR Journals Library
• Journal: Efficacy and Mechanism Evaluation
• Volume: 6
• Issue: 1
• Pages: 1-80
• Publication date: 2019-02-01
• DOI: 10.3310/eme06010
• EISSN: 2050-4373
• ISSN: 2050-4365
• Language: English
• Keywords: Medicine; Andrology; Internal medicine; Gestation; Assisted reproductive technology; Sperm; Live birth; Infertility; Obstetrics; Intracytoplasmic sperm injection; Miscarriage; Gynecology; Randomized controlled trial; Embryo transfer; Biology; Pregnancy