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Journal article

SAP controls T cell responses to virus and terminal differentiation of TH2 cells.

Abstract:

SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8+ and CD4+ interferon-gamma-producing spleen and liver cells compared to wild-type mice. The immune responses of SAP-deficient mice to infection with Leishmania major together with in vitro studies...

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Publication status:
Published

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Publisher copy:
10.1038/87713

Authors


Nguyen, KB More by this author
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Journal:
Nature immunology
Volume:
2
Issue:
5
Pages:
410-414
Publication date:
2001-05-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:2c0f9211-b1d0-4e48-9c38-cf75b1c64a12
Source identifiers:
31866
Local pid:
pubs:31866

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