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Quantitative Bayesian model-based analysis of amide proton transfer MRI

Abstract:

Amide Proton Transfer (APT) reports on contrast derived from the exchange of protons between amide groups and water. Commonly, APT contrast is quantified by asymmetry analysis, providing an ensemble contrast of both amide proton concentration and exchange rate. An alternative is to sample the off-resonant spectrum and fit an exchange model, permitting the APT effect to be quantified, correcting automatically for confounding effects of spillover, field inhomogeneity, and magnetization transfer...

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Publisher copy:
10.1002/mrm.24474

Authors


Chappell, MA More by this author
Donahue, MJ More by this author
Khrapitchev, AA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Magnetic Resonance in Medicine
Volume:
70
Issue:
2
Pages:
556-567
Publication date:
2013-08-05
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:2c0f5afc-0420-4257-bd32-5b32872d20c4
Source identifiers:
418877
Local pid:
pubs:418877

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