Journal article
Acceptability and perspectives on clinic-based urine tenofovir testing for antiretroviral therapy adherence monitoring: qualitative findings from a randomized controlled trial in South Africa
- Abstract:
- Point-of-care tenofovir (POC TFV) testing could provide a means of antiretroviral therapy (ART) adherence monitoring for people living with HIV (PLWH), allowing for earlier detection of adherence issues and timely interventions. In this qualitative study, we assessed the acceptability of a POC TFV testing intervention among PLWH and healthcare providers. We conducted in-depth interviews with 20 PLWH and eight healthcare providers participating in the STREAM HIV trial in KwaZulu-Natal, South Africa. We conducted thematic analyses of the acceptability, appropriateness, feasibility, and willingness to use the test, as well as participants’ preferred form of adherence monitoring and differentiated implementation strategies. Participants found POC TFV testing highly acceptable, appropriate, preferable to self-reporting adherence, and feasible to integrate into care. POC TFV testing was well-liked and perceived to have several positive effects. Participants’ desire to impress and build trust with their provider motivated them to take their ART daily to achieve a positive adherence test result at each clinic visit. Nearly all PLWH preferred POC TFV testing over self-reporting their adherence, and all healthcare providers were willing to use the test in routine care. Overall, POC TFV testing may be an acceptable and beneficial tool for improving HIV care and strengthening client-provider relations.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 384.1KB, Terms of use)
-
- Publisher copy:
- 10.1080/09540121.2026.2670486
Authors
+ National Institute of Allergy and Infectious Diseases
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- Funder identifier:
- https://ror.org/043z4tv69
- Grant:
- 1AI147752
+ Department of Health and Social Care
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- Funder identifier:
- https://ror.org/03sbpja79
+ National Institute for Health and Care Research
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- Funder identifier:
- https://ror.org/0187kwz08
- Publisher:
- Taylor & Francis
- Journal:
- AIDS Care More from this journal
- Pages:
- 1-15
- Publication date:
- 2026-05-26
- Acceptance date:
- 2026-04-30
- DOI:
- EISSN:
-
1360-0451
- ISSN:
-
0954-0121
- Language:
-
English
- Keywords:
- Pubs id:
-
2426436
- Local pid:
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pubs:2426436
- Source identifiers:
-
W4408403208
- Deposit date:
-
2026-05-29
- ARK identifier:
Terms of use
- Copyright holder:
- Informa UK Limited
- Copyright date:
- 2026
- Rights statement:
- © 2026 Informa UK Limited, trading as Taylor & Francis Group
- Notes:
- The author accepted manuscript (AAM) of this paper has been made available under the University of Oxford's Open Access Publications Policy, and a CC BY public copyright licence has been applied.
- Licence:
- CC Attribution (CC BY)
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