Journal article icon

Journal article

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.

Abstract:

CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells. We describe the high-resolution X-ray crystallographic structures of the immunoglobulin superfamily domain of CD47 alone and in complex with the N-terminal ligand-binding domain of signal regulatory protein alpha (SIRPalpha). The unusual and convoluted interacting face of CD47, comprising the N terminus and loops at the end of the domain, intercalates with the corresp...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Expand authors...
Journal:
Molecular cell
Volume:
31
Issue:
2
Pages:
266-277
Publication date:
2008-07-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:2bc52cee-25f9-4179-9113-bbf33fb6c229
Source identifiers:
23304
Local pid:
pubs:23304

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP