Journal article
Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection
- Abstract:
- Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intraspecies competition. The potency and targeted action of bacteriocins suggests that they could be developed into clinically useful antibiotics against highly drug resistant Gram-negative pathogens for which there are few therapeutic options. Here we show that Pseudomonas aeruginosa specific bacteriocins, known as pyocins, show strong efficacy in a murine model of P. aeruginosa lung infection, with the concentration of pyocin S5 required to afford protection from a lethal infection at least 100-fold lower than the most commonly used inhaled antibiotic tobramycin. Additionally, pyocins are stable in the lung, poorly immunogenic at high concentrations and efficacy is maintained in the presence of pyocin specific antibodies after repeated pyocin administration. Bacteriocin encoding genes are frequently found in microbial genomes and could therefore offer a ready supply of highly targeted and potent antibiotics active against problematic Gram-negative pathogens.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 842.9KB, Terms of use)
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- Publisher copy:
- 10.1038/srep30201
Authors
- Publisher:
- Springer Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 6
- Issue:
- 1
- Article number:
- 30201
- Place of publication:
- England
- Publication date:
- 2016-07-22
- Acceptance date:
- 2016-06-30
- DOI:
- EISSN:
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2045-2322
- ISSN:
-
2045-2322
- Pmid:
-
27444885
- Language:
-
English
- Pubs id:
-
638258
- Local pid:
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pubs:638258
- Deposit date:
-
2020-06-12
Terms of use
- Copyright holder:
- McCaughey et al.
- Copyright date:
- 2016
- Rights statement:
- © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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