- Abstract:
-
A class of drugs successfully used for treatment of metabolic bone diseases is the nitrogen-containing bisphosphonates (N-BPs), which act by inhibiting the vital enzyme, farnesyl pyrophosphate synthase (FPPS), of the mevalonate pathway. Inhibition of FPPS by N-BPs results in the intracellular accumulation of isopentenyl pyrophosphate (IPP) and consequently induces the biosynthesis of a cytotoxic ATP analog (ApppI). Previous cell-free data has reported that N-BPs inhibit FPPS by time-dependent...
Expand abstract - Publisher copy:
- 10.1016/j.bbrc.2011.03.070
-
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- Journal:
- Biochemical and Biophysical Research Communications
- Volume:
- 407
- Issue:
- 4
- Pages:
- 663-667
- Publication date:
- 2011-04-22
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:2bbbe66b-ee05-4e44-b413-e66ce9192e38
- Source identifiers:
-
149727
- Local pid:
- pubs:149727
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
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