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Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells

Abstract:

A class of drugs successfully used for treatment of metabolic bone diseases is the nitrogen-containing bisphosphonates (N-BPs), which act by inhibiting the vital enzyme, farnesyl pyrophosphate synthase (FPPS), of the mevalonate pathway. Inhibition of FPPS by N-BPs results in the intracellular accumulation of isopentenyl pyrophosphate (IPP) and consequently induces the biosynthesis of a cytotoxic ATP analog (ApppI). Previous cell-free data has reported that N-BPs inhibit FPPS by time-dependent...

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Publisher copy:
10.1016/j.bbrc.2011.03.070

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Biochemical and Biophysical Research Communications
Volume:
407
Issue:
4
Pages:
663-667
Publication date:
2011-04-22
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:2bbbe66b-ee05-4e44-b413-e66ce9192e38
Source identifiers:
149727
Local pid:
pubs:149727

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