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Journal article

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction.

Abstract:

NKT cells recognize lipid Ags presented by CD1d molecules and play an important role in the regulation of innate and adaptive immune responses. In this study, we report the identification of a membrane-associated protein, Ig-like transcript 4 (ILT4), as a novel human CD1d receptor that inhibits CD1d-mediated immune responses. We found that native CD1d tetramer generated by mammalian cells was able to specifically bind human monocytes in the peripheral blood, and this binding was at least part...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.182.2.1033

Authors


Freundt, EC More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
182
Issue:
2
Pages:
1033-1040
Publication date:
2009-01-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:2bb68653-031d-421d-aa81-0e51c4ae45dd
Source identifiers:
95791
Local pid:
pubs:95791

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