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Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

Abstract:

Japanese encephalitis virus is a leading cause of neurological infection in the Asia-Pacific region with no means of detection in more remote areas. We aimed to test the hypothesis of a Japanese encephalitis (JE) protein signature in human cerebrospinal fluid (CSF) that could be harnessed in a rapid diagnostic test (RDT), contribute to understanding the host response and predict outcome during infection. Liquid chromatography and tandem mass spectrometry (LC–MS/MS), using extensive offline fr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jproteome.2c00563

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-6772-2855
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-7466-2977

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Contributor
Publisher:
American Chemical Society
Journal:
Journal of Proteome Research More from this journal
Volume:
22
Issue:
6
Pages:
1614–1629
Publication date:
2023-05-23
Acceptance date:
2023-03-28
DOI:
EISSN:
1535-3907
ISSN:
1535-3893

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