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Lipid loving ANTs: Molecular simulations of cardiolipin interactions and the organization of the adenine nucleotide translocase in model mitochondrial membranes

Abstract:

The exchange of ADP and ATP across the inner mitochondrial membrane is a fundamental cellular process. This exchange is facilitated by the adenine nucleotide translocase (ANT), the structure and function of which is critically dependent on the signature phospholipid of mitochondria, cardiolipin (CL). Here we employ multiscale molecular dynamics simulations to investigate CL interactions within a membrane environment. Using simulations at both coarse-grained (CG) and atomistic (AT) resolutions...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/acs.biochem.6b00751

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Engineering and Physical Sciences Research Council More from this funder
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Publisher:
American Chemical Society Publisher's website
Journal:
Biochemistry Journal website
Volume:
55
Issue:
45
Pages:
6238–6249
Publication date:
2016-10-05
Acceptance date:
2016-10-27
DOI:
ISSN:
1520-4995 and 0006-2960
Pubs id:
pubs:655571
URN:
uri:2b8f782e-e196-44b8-bc3f-30882feb0da6
UUID:
uuid:2b8f782e-e196-44b8-bc3f-30882feb0da6
Local pid:
pubs:655571

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