Tetrahydrobiopterin is a cofactor synthesized from GTP with well-known roles in enzymatic nitric oxide synthesis and aromatic amino acid hydroxylation. It is used to treat mild forms of phenylketonuria. Less is known about the role of tetrahydrobiopterin in lipid metabolism, although it is essential for irreversible ether lipid cleavage by alkylglycerol monooxygenase. Here we found intracellular alkylglycerol monooxygenase activity to be an important regulator of alkylglycerol metabolism in i...Expand abstract
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- Peer reviewed
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- National Academy of Sciences Publisher's website
- Proceedings of the National Academy of Sciences of the United States of America Journal website
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- Watschinger et al.
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- Copyright © 2015 Watschinger et al.
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
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