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Opiate peptides control growth hormone through a cholinergic mechanism in man.

Abstract:
Opiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Clinical endocrinology
Volume:
18
Issue:
4
Pages:
401-405
Publication date:
1983-04-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:2b35a9c5-13a5-4ba2-a816-423cc024a51b
Source identifiers:
138662
Local pid:
pubs:138662

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