Journal article : Review
Genetic-guided pharmacotherapy for venous thromboembolism: a systematic and critical review of economic evaluations
- Abstract:
- Despite the known contributions of genes, genetic-guided pharmacotherapy has not been routinely implemented for venous thromboembolism (VTE). To examine evidence on cost-effectiveness of genetic-guided pharmacotherapy for VTE, we searched six databases, websites of four HTA agencies and citations, with independent double-reviewers in screening, data extraction, and quality rating. The ten eligible studies, all model-based, examined heterogeneous interventions and comparators. Findings varied widely; testing was cost-saving in two base-cases, cost-effective in four, not cost-effective in three, dominated in one. Of 22 model variables that changed decisions about cost-effectiveness, effectiveness/relative effectiveness of the intervention was the most frequent, albeit of poor quality. Studies consistently lacked details on the provision of interventions and comparators as well as on model development and validation. Besides improving the reporting of interventions, comparators, and methodological details, future economic evaluations should examine strategies recommended in guidelines and testing key model variables for decision uncertainty, to advise clinical implementations.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.9MB, Terms of use)
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- Publisher copy:
- 10.1038/s41397-021-00243-7
Authors
- Publisher:
- Springer Nature
- Journal:
- Pharmacogenomics Journal More from this journal
- Volume:
- 21
- Issue:
- 6
- Pages:
- 625–637
- Place of publication:
- United States
- Publication date:
- 2021-06-15
- Acceptance date:
- 2021-05-19
- DOI:
- EISSN:
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1473-1150
- ISSN:
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1470-269X
- Pmid:
-
34131314
- Language:
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English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1182250
- Local pid:
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pubs:1182250
- Deposit date:
-
2021-08-25
Terms of use
- Copyright holder:
- Lim et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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