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Structural basis of Latrophilin-FLRT interaction

Abstract:

Latrophilins, receptors for spider venom α-latrotoxin, are adhesion type G-protein-coupled receptors with emerging functions in synapse development. The N-terminal region binds the endogenous cell adhesion molecule FLRT, a major regulator of cortical and synapse development. We present crystallographic data for the mouse Latrophilin3 lectin and olfactomedin-like (Olf) domains, thereby revealing the Olf β-propeller fold and conserved calcium-binding site. We locate the FLRT-Latrophilin binding...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Biochemistry
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Department:
Biochemistry
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Department:
Biochemistry
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Department:
Structural Biology
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Publisher:
Elsevier Publisher's website
Journal:
Structure
Volume:
23
Issue:
4
Pages:
774-781
Publication date:
2015-02-26
Acceptance date:
2015-01-19
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
UUID:
uuid:2ad757fe-e0b1-4ce8-81ba-777ae1b567d6
Deposit date:
2015-05-27

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