- Abstract:
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Latrophilins, receptors for spider venom α-latrotoxin, are adhesion type G-protein-coupled receptors with emerging functions in synapse development. The N-terminal region binds the endogenous cell adhesion molecule FLRT, a major regulator of cortical and synapse development. We present crystallographic data for the mouse Latrophilin3 lectin and olfactomedin-like (Olf) domains, thereby revealing the Olf β-propeller fold and conserved calcium-binding site. We locate the FLRT-Latrophilin binding...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
-
(pdf, 2.6MB)
-
- Publisher copy:
- 10.1016/j.str.2015.01.013
-
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- Grant:
- SFB 834; EXC 115
- Funding agency for:
- Project
- Publisher:
- Elsevier Publisher's website
- Journal:
- Structure
- Volume:
- 23
- Issue:
- 4
- Pages:
- 774-781
- Publication date:
- 2015-02-26
- Acceptance date:
- 2015-01-19
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Language:
- English
Journal article
Structural basis of Latrophilin-FLRT interaction
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