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hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia.

Abstract:

Telomere shortening is associated with disease progression in chronic myeloid leukaemia (CML). To investigate the biology and regulation of telomerase in CML, we evaluated expression of the telomerase components, its regulators and several telomeric-associated proteins. Quantitative real-time-polymerase chain reaction (PCR) was used to compare gene expression in the CD34+/leukaemic blast cells of 22 CML patient samples to the CD34+ cell population of healthy individuals. hTERT, the catalytic ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.leu.2404141

Authors


Campbell, LJ More by this author
Eagleton, H More by this author
Peniket, A More by this author
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Journal:
Leukemia
Volume:
20
Issue:
4
Pages:
671-679
Publication date:
2006-04-05
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:2aae5fa8-e613-472d-bd43-20c75a107eb5
Source identifiers:
246227
Local pid:
pubs:246227

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