- Abstract:
-
It has been established that a total of 250 microg of monoclonal anti-mouse CD3 F(ab')(2) fragments, administered daily (50 microg per dose), induces remission of diabetes in the non-obese diabetic (NOD) mouse model of autoimmune diabetes by preventing beta cells from undergoing further autoimmune attack. We evaluated lower-dose regimens of monoclonal anti-CD3 F(ab')(2) in diabetic NOD mice for their efficacy and associated pharmacodynamic (PD) effects, including CD3-T-cell receptor (TCR) com...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2567.2009.03217.x
-
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- Journal:
- Immunology
- Volume:
- 130
- Issue:
- 1
- Pages:
- 103-113
- Publication date:
- 2010-05-05
- DOI:
- EISSN:
-
1365-2567
- ISSN:
-
0019-2805
- URN:
-
uuid:2aa746fa-6758-4847-b90a-998492be87de
- Source identifiers:
-
45922
- Local pid:
- pubs:45922
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice.
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