Journal article
Clinical performance status and technical factors affecting outcomes from percutaneous transhepatic biliary interventions; a multicentre, prospective, observational cohort study
- Abstract:
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Purpose: The purpose of this study was to evaluate the predictive value of a ‘Modified Karnofsky Scoring System’ on outcomes and provide real-world data regarding the UK practice of biliary interventions.
Materials and Methods: A prospective multi-centred cohort study was performed. The pre-procedure modified Karnofsky score, the incidence of sepsis, complications, biochemical improvement and mortality were recorded out to 30 days post procedure.
Results: A total of 292 patients (248 with malignant lesions) were suitable for inclusion in the study. The overall 7 and 30 day mortality was 3.1% and 16.1%, respectively. The 30 day sepsis rate was 10.3%. In the modified Karnofsky ‘high risk’ group the 7 day mortality was 9.7% versus 0% for the ‘low risk’ group (p = 0.002), whereas the 30 day mortality was 28.8% versus 13.3% (p = 0.003). The incidence of sepsis at 30 days was 19% in the high risk group versus 3.3% at the low risk group (p = 0.001)
Conclusion: Percutaneous biliary interventions in the UK are safe and effective. Scoring systems such as the Karnofsky or the modified Karnofsky score hold promise in allowing us to identify high risk groups that will need more careful consideration and enhanced patient informed consent but further research with larger studies is warranted in order to identify their true impact on patient selection and outcomes post biliary interventions.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 370.3KB, Terms of use)
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- Publisher copy:
- 10.1007/s00270-021-02888-0
Authors
- Publisher:
- Springer
- Journal:
- CardioVascular and Interventional Radiology More from this journal
- Volume:
- 44
- Issue:
- 10
- Pages:
- 1625-1632
- Place of publication:
- United States
- Publication date:
- 2021-07-12
- Acceptance date:
- 2021-05-28
- DOI:
- EISSN:
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1432-086X
- ISSN:
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0174-1551
- Pmid:
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34254176
- Language:
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English
- Keywords:
- Pubs id:
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1186753
- Local pid:
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pubs:1186753
- Deposit date:
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2023-05-28
Terms of use
- Copyright holder:
- Makris et al
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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