Journal article : Review
Design, methods, and reporting of impact studies of cardiovascular clinical prediction rules are suboptimal: a systematic review
- Abstract:
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Objectives
To evaluate design, methods, and reporting of impact studies of cardiovascular clinical prediction rules (CPRs).Study Design and Setting
We conducted a systematic review. Impact studies of cardiovascular CPRs were identified by forward citation and electronic database searches. We categorized the design of impact studies as appropriate for randomized and nonrandomized experiments, excluding uncontrolled before-after study. For impact studies with appropriate study design, we assessed the quality of methods and reporting. We compared the quality of methods and reporting between impact and matched control studies.Results
We found 110 impact studies of cardiovascular CPRs. Of these, 65 (59.1%) used inappropriate designs. Of 45 impact studies with appropriate design, 31 (68.9%) had substantial risk of bias. Mean number of reporting domains that impact studies with appropriate study design adhered to was 10.2 of 21 domains (95% confidence interval, 9.3 and 11.1). The quality of methods and reporting was not clearly different between impact and matched control studies.Conclusion
We found most impact studies either used inappropriate study design, had substantial risk of bias, or poorly complied with reporting guidelines. This appears to be a common feature of complex interventions. Users of CPRs should critically evaluate evidence showing the effectiveness of CPRs.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Supplementary materials, zip, 688.3KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1016/j.jclinepi.2021.01.016
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of Clinical Epidemiology More from this journal
- Volume:
- 133
- Pages:
- 111-120
- Publication date:
- 2021-01-26
- Acceptance date:
- 2021-01-21
- DOI:
- EISSN:
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1878-5921
- ISSN:
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0895-4356
- Pmid:
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33515655
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1159149
- Local pid:
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pubs:1159149
- Deposit date:
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2021-02-17
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Elsevier Inc. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://doi.org/10.1016/j.jclinepi.2021.01.016
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