Journal article
Plasmodium falciparum-specific memory B-cell and antibody responses are associated with immunity in children living in an endemic area of Kenya
- Abstract:
- Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum malaria could contribute to the design of effective malaria vaccines. Using a recently developed multiplexed FluoroSpot assay, we assessed cross-sectional pre-existing memory B-cells (MBCs) and antibody responses against six well known P. falciparum antigens (MSP-119, MSP-2 (3D7), MSP-2 (FC27), MSP-3, AMA-1 and CSP) and measured their associations with previous infections and time to clinical malaria in the ensuing malaria season in Kenyan children. These children were under active weekly surveillance for malaria as part of a long-term longitudinal malaria immunology cohort study, where they are recruited from birth. After performing Cox regression analysis, we found that children with a breadth of three or more antigen-specific MBC or antibody responses at the baseline had a reduced risk for malaria in the ensuing P. falciparum transmission season. Specifically, MBC responses against AMA-1, MSP-2 (3D7) and MSP-3, as well as antibody responses to MSP-2 (3D7) and MSP-3 were prospectively associated with a reduced risk for malaria. The magnitude or breadth of MBC responses were however not correlated with the cumulative number of malaria episodes since birth. We conclude that increased breadth for merozoite antigen-specific MBC and antibody responses is associated with protection against malaria.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 2.8MB, Terms of use)
-
- Publisher copy:
- 10.3389/fimmu.2022.799306
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 13
- Article number:
- 799306
- Publication date:
- 2022-03-09
- Acceptance date:
- 2022-02-16
- DOI:
- EISSN:
-
1664-3224
- Pmid:
-
35355994
- Language:
-
English
- Keywords:
- Pubs id:
-
1257046
- Local pid:
-
pubs:1257046
- Deposit date:
-
2022-06-10
- ARK identifier:
Terms of use
- Copyright holder:
- Jahnmatz et al.
- Copyright date:
- 2022
- Rights statement:
- ©2022 Jahnmatz, Nyabundi, Sundling, Widman, Mwacharo, Musyoki, Otieno, Ahlborg, Bejon, Ndungu and Färnert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record