Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide

Journal article

Two drug-inorganic composites involving vitamin C (VC) intercalated in Mg-Al and Mg-Fe layered double hydroxides (LDHs) have been synthesized by the calcination-rehydration (reconstruction) method. Powder X-ray diffraction (XRD), Fourier transform infrared (FTIR), and UV-vis absorption spectroscopy indicate a successful intercalation of VC into the interlayer galleries of the LDH host. Studies of VC release from the LDHs in deionised water and in aqueous CO solutions imply that MgAl-VC LDH is a better controlled release system than MgFe-VC LDH. Analysis of the release profiles using a number of kinetic models suggests a solution-dependent release mechanism, and a diffusion-controlled deintercalation mechanism in deionised water, but an ion exchange process in CO solution. © 2013 Elsevier Inc. All rights reserved.

Authors: Gao, X; Lei, L; O'Hare, D; Xie, J; Gao, P

• Publication status: Published
• Journal: JOURNAL OF SOLID STATE CHEMISTRY
• Volume: 203
• Pages: 174-180
• Publication date: 2013-07-01
• DOI: 10.1016/j.jssc.2013.04.028
• EISSN: 1095-726X
• ISSN: 0022-4596
• Keywords: Controlled release; Layered double hydroxide; Vitamin C; Intercalation