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Engineered pores for stochastic sensing and single molecule studies

Abstract:

Stochastic sensing is a powerful approach for the detection of a range of analytes, yielding information at the single molecule level. Protein pores engineered for the binding of desired analytes are inserted into planar lipid bilayers and analyte binding is detected by observing the modulation of current flowing through the pore under an applied potential.

In this work, two complementary approaches for the detection of protein analytes were investigated. Chapter 2 describes the dev...

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Leon Harrington More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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