Journal article
Macrophage anti-inflammatory behaviour in a multiphase model of atherosclerotic plaque development
- Abstract:
- Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. The inflammation is often non-resolving, due in large part to changes in normal macrophage anti-inflammatory behaviour that are induced by the toxic plaque microenvironment. These changes include higher death rates, defective efferocytic uptake of dead cells, and reduced rates of emigration. We develop a free boundary multiphase model for early atherosclerotic plaques, and we use it to investigate the effects of impaired macrophage anti-inflammatory behaviour on plaque structure and growth. We find that high rates of cell death relative to efferocytic uptake results in a plaque populated mostly by dead cells. We also find that emigration can potentially slow or halt plaque growth by allowing material to exit the plaque, but this is contingent on the availability of live macrophage foam cells in the deep plaque. Finally, we introduce an additional bead species to model macrophage tagging via microspheres, and we use the extended model to explore how high rates of cell death and low rates of efferocytosis and emigration prevent the clearance of macrophages from the plaque.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1007/s11538-023-01142-7
Authors
- Publisher:
- Springer
- Journal:
- Bulletin of Mathematical Biology More from this journal
- Volume:
- 85
- Issue:
- 5
- Article number:
- 37
- Publication date:
- 2023-03-29
- Acceptance date:
- 2023-03-09
- DOI:
- EISSN:
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1522-9602
- ISSN:
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0092-8240
- Language:
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English
- Keywords:
- Pubs id:
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1336352
- Local pid:
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pubs:1336352
- Deposit date:
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2023-04-28
- ARK identifier:
Terms of use
- Copyright holder:
- Ahmed et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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