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Genome sequencing of an extended series of NDM-producing Klebsiella pneumoniae isolates from neonatal infections in a Nepali hospital characterizes the extent of community- versus hospital-associated transmission in an endemic setting.

Abstract:

NDM-producing Klebsiella pneumoniae strains represent major clinical and infection control challenges, particularly in resource-limited settings with high rates of antimicrobial resistance. Determining whether transmission occurs at a gene, plasmid, or bacterial strain level and within hospital and/or the community has implications for monitoring and controlling spread. Whole-genome sequencing (WGS) is the highest-resolution typing method available for transmission epidemiology. We sequenced ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.03900-14

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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National Institute for Health Research More from this funder
Medical Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Department of Health More from this funder
Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial agents and chemotherapy Journal website
Volume:
58
Issue:
12
Pages:
7347-7357
Publication date:
2014-12-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:2a329e78-3ef2-425f-9e1a-59cae299ecea
Source identifiers:
485666
Local pid:
pubs:485666

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