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Effect of psychotropic medications on suicide-related outcomes: a systematic review and meta-analysis of observational studies

Abstract:

BackgroundPsychiatric disorders are associated with increased risk of suicide-related outcomes, and the impact of pharmacological treatments on these outcomes is uncertain. Although randomised controlled trials are the main approach to evaluate efficacy, they may not provide externally valid results for suicide prevention in psychiatric populations. Thus, we aimed to synthesise the evidence on the effect of psychotropic medications on suicide-related outcomes from observational studies.Method...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.eclinm.2026.103800

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Sub department:
Psychiatry
Role:
Author
ORCID:
0009-0007-4903-7495
More by this author
Institution:
University of Oxford
Division:
SSD
Department:
Social Policy & Intervention
Sub department:
Social Policy & Intervention
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Sub department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Sub department:
Psychiatry
Role:
Author


More from this funder
Funder identifier:
10.13039/501100004789
More from this funder
Funder identifier:
10.13039/501100013373
More from this funder
Funder identifier:
10.13039/100010269
More from this funder
Funder identifier:
10.13039/501100004359


Publisher:
Elsevier
Journal:
EClinicalMedicine More from this journal
Volume:
93
Pages:
103800
Article number:
103800
Publication date:
2026-02-21
DOI:
EISSN:
2589-5370
ISSN:
2589-5370
Pmid:
41768277


Language:
English
Keywords:
Pubs id:
2382252
Local pid:
pubs:2382252
Source identifiers:
3836682
Deposit date:
2026-03-10
ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.

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