- Abstract:
-
INTRODUCTION: Blockade of the CD40-CD154 costimulatory pathway can prolong allograft survival, but does not prevent the development of transplant arteriosclerosis in several models. In this study, we investigated the mechanisms of CD40-CD154-independent transplant arteriosclerosis in major histocompatibility complex (MHC)-class I-mismatched aortic allografts. METHODS: MHC class I-mismatched CBK (H2k+Kb) donor aortas were transplanted into CBA (H2k) recipients who can only recognize the graft...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/tp.0b013e31818bbd3a
-
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- Journal:
- Transplantation
- Volume:
- 86
- Issue:
- 11
- Pages:
- 1615-1621
- Publication date:
- 2008-12-05
- DOI:
- EISSN:
-
1534-6080
- ISSN:
-
0041-1337
- URN:
-
uuid:2a02d72b-9f3f-4d02-8ab8-ed791e9ea2e7
- Source identifiers:
-
136063
- Local pid:
- pubs:136063
- Copyright date:
- 2008
Journal article
Neutralizing interleukin-4 prevents transplant arteriosclerosis mediated by indirect pathway T cells under CD40-CD154 costimulation blockade.
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