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Neutralizing interleukin-4 prevents transplant arteriosclerosis mediated by indirect pathway T cells under CD40-CD154 costimulation blockade.

Abstract:

INTRODUCTION: Blockade of the CD40-CD154 costimulatory pathway can prolong allograft survival, but does not prevent the development of transplant arteriosclerosis in several models. In this study, we investigated the mechanisms of CD40-CD154-independent transplant arteriosclerosis in major histocompatibility complex (MHC)-class I-mismatched aortic allografts. METHODS: MHC class I-mismatched CBK (H2k+Kb) donor aortas were transplanted into CBA (H2k) recipients who can only recognize the graft...

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Publication status:
Published

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Publisher copy:
10.1097/tp.0b013e31818bbd3a

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
86
Issue:
11
Pages:
1615-1621
Publication date:
2008-12-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:2a02d72b-9f3f-4d02-8ab8-ed791e9ea2e7
Source identifiers:
136063
Local pid:
pubs:136063

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