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Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter.

Abstract:

IL-10 plays an essential role in blocking cytokine production by activated macrophages. To analyze the consequences of enforced expression of IL-10 by macrophages on innate and adaptive immune responses, we generated transgenic mice (macIL-10tg mice) expressing an epitope-tagged IL-10 (Flag-IL-10) under control of the human CD68 promoter. Expression of Flag-IL-10 was constitutive and restricted to macrophages, as shown by sorting splenocyte cell populations and intracellular staining for IL-1...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.168.7.3402

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
168
Issue:
7
Pages:
3402-3411
Publication date:
2002-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:29ccb5c1-75db-410d-a337-6e0180845a62
Source identifiers:
7111
Local pid:
pubs:7111

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