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Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B

Abstract:

Many viruses are enveloped by a lipid bilayer acquired during assembly, which is typically studded with one or two types of glycoproteins. These viral surface proteins act as the primary interface between the virus and the host. Entry of enveloped viruses relies on specialized fusogen proteins to help merge the virus membrane with the host membrane. In the multicomponent herpesvirus fusion machinery, glycoprotein B (gB) acts as this fusogen. Although the structure of the gB ectodomain postfus...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Authors


Zeev-Ben-Mordehai, T More by this author
Vasishtan, D More by this author
Durán, AH More by this author
Vollmer, B More by this author
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
113
Issue:
15
Pages:
4176-4181
Publication date:
2016-04-12
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:29cb47f4-c532-4f01-a880-02ffe2733efc
Source identifiers:
618121
Local pid:
pubs:618121
Keywords:

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