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Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents.

Abstract:

Malaria remains a significant infectious disease with even artemisinin-based therapies now facing resistance in the field. Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with 'chemosensitizers' or 'chemoreversal' agents (CRA). Concerning the latter, we have focused on the resistance mechanisms developed against chloroquine (CQ). We have synthesized a series of compounds related to pre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.ejmech.2016.04.058

Authors


Boudhar, A More by this author
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Publisher:
Elsevier Publisher's website
Journal:
European Journal of Medicinal Chemistry Journal website
Volume:
119
Pages:
231-249
Publication date:
2016-04-29
DOI:
EISSN:
1768-3254
ISSN:
0223-5234
URN:
uuid:29c4a487-0a78-4157-8334-030cd297c60b
Source identifiers:
623544
Local pid:
pubs:623544

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