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Journal article

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.

Abstract:

AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that plays a key role in the regulation of energy metabolism. In humans, mutations in the gamma2-subunit of AMPK cause cardiac hypertrophy associated with Wolff-Parkinson-White syndrome, characterized by ventricular preexcitation. The effect of these mutations on AMPK activity and in development of the disease is enigmatic. Here we report that transgenic mice with cardiac-specific expression of gamma2 ...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.01020.2005

Authors


Davies, JK More by this author
Whitrow, HR More by this author
Daniel, TD More by this author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
290
Issue:
5
Pages:
H1942-H1951
Publication date:
2006-05-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:29c40fe4-ecc1-4753-9ed8-e953f9992c24
Source identifiers:
104246
Local pid:
pubs:104246

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