Journal article
The global distribution and spread of the mobilized colistin resistance gene mcr-1
- Abstract:
- Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002-2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 937.8KB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-018-03205-z
Authors
+ Engineering and Physical Sciences Research Council
More from this funder
- Funding agency for:
- Shaw, L
- Grant:
- EP/F500351/1
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 9
- Pages:
- 1179
- Publication date:
- 2018-03-21
- Acceptance date:
- 2018-01-29
- DOI:
- EISSN:
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2041-1723
- Pmid:
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29563494
- Language:
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English
- Pubs id:
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pubs:831011
- UUID:
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uuid:299b8c4d-af82-4ed4-9332-5254c826d5b3
- Local pid:
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pubs:831011
- Source identifiers:
-
831011
- Deposit date:
-
2018-09-10
Terms of use
- Copyright holder:
- Wang et al
- Copyright date:
- 2018
- Notes:
-
© The Author(s) 2018. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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