Journal article
Nonregistration, discontinuation, and nonpublication of randomized trials: a repeated metaresearch analysis
- Abstract:
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Background
We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, and 44% remained unpublished at a median of 12 years follow-up. We aimed to assess a decade later (1) whether rates of completion and publication have increased; (2) the extent to which nonpublished RCTs can be identified in trial registries; and (3) the association between reporting quality of protocols and premature discontinua... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 595.6KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pmed.1003980
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Medicine More from this journal
- Volume:
- 19
- Issue:
- 4
- Article number:
- e1003980
- Place of publication:
- United States
- Publication date:
- 2022-04-27
- Acceptance date:
- 2022-04-01
- DOI:
- EISSN:
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1549-1676
- ISSN:
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1549-1277
- Pmid:
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35476675
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1256996
- Local pid:
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pubs:1256996
- Deposit date:
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2022-06-06
Terms of use
- Copyright holder:
- Speich et al.
- Copyright date:
- 2022
- Rights statement:
- ©2022 Speich et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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