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Naked dense bodies provoke depression.

Abstract:

At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brpnude, lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brpnude, electron-dense bodies were properly shaped, though entirely bare of synaptic vesicles. While basal glutamate release was unchanged, paired...

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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
30
Issue:
43
Pages:
14340-14345
Publication date:
2010-10-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:2943e760-97ac-4858-a3c7-307d5c36addb
Source identifiers:
345846
Local pid:
pubs:345846

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