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Synthesis of Imidazolidin-4-ones via a Cytochrome P450-Catalyzed Intramolecular C−H Amination

Abstract:

Expanding Nature’s catalytic repertoire to include reactions important in synthetic chemistry opens new opportunities for biocatalysis. An intramolecular C–H amination route to imidazolidin-4-ones via α-functionalization of 2-aminoacetamides catalyzed by evolved variants of cytochrome P450BM3 (CYP102A1) from Bacillus megaterium has been developed. Screening of a library of ca. 100 variants based on four template mutants with enhanced activity for the oxidation of unnatural substrates and prep...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
  • (Accepted manuscript, pdf, 394.5KB)
Publisher copy:
10.1021/acscatal.6b02189

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More from this funder
Name:
Syngenta
Funding agency for:
O'Hanlon, J
Grant:
EP/L505031/1
More from this funder
Name:
Engineering and Physical Sciences Research Counci
Funding agency for:
O'Hanlon, J
Grant:
EP/L505031/1
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/L024381/1
More from this funder
Name:
China Oxford Scholarship Fund
Funding agency for:
Ren, X
Publisher:
American Chemical Society
Journal:
ACS Catalysis More from this journal
Volume:
6
Issue:
10
Pages:
6833–6837
Publication date:
2016-09-01
Acceptance date:
2016-09-01
DOI:
ISSN:
2155-5435
Keywords:
Pubs id:
pubs:656753
UUID:
uuid:28f8e05a-a32a-4a2b-8d30-ed2b674c1f95
Local pid:
pubs:656753
Source identifiers:
656753
Deposit date:
2016-11-02

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