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Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes

Abstract:

Transcription initiation is a major step in gene regulation for all organisms. In bacteria, the promoter DNA is first recognized by RNA polymerase (RNAP) to yield an initial closed complex. This complex subsequently undergoes conformational changes resulting in DNA strand separation to form a transcription bubble and an RNAP-promoter open complex; however, the series and sequence of conformational changes, and the factors that influence them are unclear. To address the conformational landscap...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics; Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics; Condensed Matter Physics
Role:
Author
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/J00054X/1
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Name:
European Research Council
Grant:
Starter grant [261227 to A.N.K.
More from this funder
Name:
Clarendon Fund
Grant:
Scholarship from the University of Oxford (to K.G.
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
DTA Studentship (to D.D.
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research More from this journal
Volume:
46
Issue:
2
Pages:
677–688
Publication date:
2017-11-21
Acceptance date:
2017-10-31
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:826828
UUID:
uuid:28ea3024-bf66-4ff9-84d6-5ffe6c5ddfa1
Local pid:
pubs:826828
Deposit date:
2018-02-27

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