Journal article
B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity
- Abstract:
- This post hoc analysis of the randomized, placebo-controlled N-MOmentum study (NCT02200770) of inebilizumab in neuromyelitis optica spectrum disorder (NMOSD) evaluated relationships between circulating B-cell subsets and aquaporin-4 immunoglobulin G (AQP4-lgG) titers and attacks. Among participants receiving placebo, CD20+ and CD27+ B-cell counts were modestly increased from the pre-attack visit to attack; plasmablast/plasma cell gene signature was increased from baseline to the pre-attack visit (p = 0.016) and from baseline to attack (p = 0.009). With inebilizumab treatment, B-cell subset counts decreased and did not increase with attacks. No difference in change of AQP4-IgG titers from baseline to time of attack was observed.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 825.4KB, Terms of use)
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- Publisher copy:
- 10.1002/acn3.52171
Authors
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/V007173/1
- Publisher:
- Wiley
- Journal:
- Annals of Clinical and Translational Neurology More from this journal
- Volume:
- 11
- Issue:
- 10
- Pages:
- 2792-2798
- Place of publication:
- United States
- Publication date:
- 2024-09-02
- Acceptance date:
- 2024-07-15
- DOI:
- EISSN:
-
2328-9503
- Pmid:
-
39222408
- Language:
-
English
- Pubs id:
-
2026541
- Local pid:
-
pubs:2026541
- Deposit date:
-
2025-02-05
Terms of use
- Copyright holder:
- Bennett et al
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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