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Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens

Abstract:
Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tim.2021.03.007

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
ORCID:
0000-0002-2373-3405
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author



Publisher:
Cell Press
Journal:
Trends in Microbiology More from this journal
Volume:
29
Issue:
12
Pages:
1058-1061
Publication date:
2021-04-06
Acceptance date:
2021-03-12
DOI:
EISSN:
1878-4380
ISSN:
0966-842X


Language:
English
Keywords:
Pubs id:
1168862
Local pid:
pubs:1168862
Deposit date:
2021-03-22

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