Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments

Journal article

Deterministic continuum models formulated as non-local partial differential equations for the evolutionary dynamics of populations structured by phenotypic traits have been used recently to address open questions concerning the adaptation of asexual species to periodically fluctuating environmental conditions. These models are usually defined on the basis of population-scale phenomenological assumptions and cannot capture adaptive phenomena that are driven by stochastic variability in the evolutionary paths of single individuals. In light of these considerations, in this paper we develop a stochastic individual-based model for the coevolution of two competing phenotype-structured cell populations that are exposed to time-varying nutrient levels and undergo spontaneous, heritable phenotypic changes with different probabilities. Here, the evolution of every cell is described by a set of rules that result in a discrete-time branching random walk on the space of phenotypic states, and nutrient levels are governed by a difference equation in which a sink term models nutrient consumption by the cells. We formally show that the deterministic continuum counterpart of this model comprises a system of non-local partial differential equations for the cell population density functions coupled with an ordinary differential equation for the nutrient concentration. We compare the individual-based model and its continuum analogue, focussing on scenarios whereby the predictions of the two models differ. The results obtained clarify the conditions under which significant differences between the two models can emerge due to bottleneck effects that bring about both lower regularity of the density functions of the two populations and more pronounced demographic stochasticity. In particular, bottleneck effects emerge in the presence of lower probabilities of phenotypic variation, and are more apparent when the two populations are characterised by lower fitness initial mean phenotypes and smaller initial levels of phenotypic heterogeneity. The emergence of these effects, and thus the agreement between the two modelling approaches, is also dependent on the initial proportions of the two populations. As an illustrative example, we demonstrate the implications of these results in the context of the mathematical modelling of the early stage of metastatic colonisation of distant organs.

Authors: Ardaseva, A; Anderson, A; Gatenby, R; Byrne, H; Maini, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Physical Society
• Journal: Physical Review E: Statistical, Nonlinear, and Soft Matter Physics
• Volume: 102
• Article number: 042404
• Publication date: 2020-10-08
• Acceptance date: 2020-09-15
• DOI: 10.1103/PhysRevE.102.042404
• EISSN: 1550-2376
• ISSN: 1539-3755
• Language: English
• Keywords: FFR