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Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research

Abstract:

A new first-line antiretroviral therapy (ART) regimen containing dolutegravir is being rolled-out in low-income and middle-income countries (LMICs). Studies from predominantly high-income settings have found that dolutegravir-based regimens have superior efficacy, tolerability and durability compared with existing first-line regimens. However, several questions remain regarding the roll-out of dolutegravir in LMICs, where most people living with HIV are women of reproductive age, TB prevalenc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/s2352-3018(18)30093-6

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Oxford college:
Green Templeton
ORCID:
0000-0001-6072-1430
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ORCID:
0000-0003-0926-710X
De Oliveira, T More by this author
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South African Medical Research Council More from this funder
Department of Science and Technology More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet HIV Journal website
Volume:
5
Issue:
7
Pages:
e400-e404
Publication date:
2018-06-05
Acceptance date:
2018-04-18
DOI:
EISSN:
2352-3018
ISSN:
2405-4704
Pubs id:
pubs:925481
URN:
uri:2831238e-2fd2-47c7-9fed-010710555f4c
UUID:
uuid:2831238e-2fd2-47c7-9fed-010710555f4c
Local pid:
pubs:925481

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