Journal article
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
- Abstract:
- Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral therapy naïve, HIV-1 infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were significantly more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers predictive of progression.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1038/nm.4161
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Medicine More from this journal
- Volume:
- 22
- Issue:
- 10
- Pages:
- 1090-1093
- Publication date:
- 2016-09-01
- Acceptance date:
- 2016-07-08
- DOI:
- EISSN:
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1546-170X
- ISSN:
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1078-8956
- Pmid:
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27595321
- Language:
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English
- Pubs id:
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pubs:652356
- UUID:
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uuid:282b2e67-ec6c-4a87-8101-29b2f9b1d228
- Local pid:
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pubs:652356
- Source identifiers:
-
652356
- Deposit date:
-
2016-10-13
- ARK identifier:
Terms of use
- Copyright holder:
- Esmail et al
- Copyright date:
- 2016
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/nm.4161
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