Journal article
Hydrosulfonylation of alkenes with sulfonyl chlorides under visible light activation
- Abstract:
- Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, we report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly effective photoredox‐catalyzed hydrosulfonylation of electron‐deficient alkenes with sulfonyl chlorides. To increase the generality of this transformation, polarity‐reversal catalysis (PRC) was successfully implemented for alkenes bearing alkyl substituents. This late‐stage functionalization method tolerates a remarkably wide range of functional groups, is operationally simple, scalable, and allows access to building blocks which are important for medicinal chemistry and drug discovery.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 6.2MB, Terms of use)
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- Publisher copy:
- 10.1002/anie.202004070
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie International Edition More from this journal
- Volume:
- 59
- Issue:
- 28
- Pages:
- 11620-11626
- Publication date:
- 2020-04-14
- Acceptance date:
- 2020-04-14
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Language:
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English
- Keywords:
- Pubs id:
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1100659
- Local pid:
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pubs:1100659
- Deposit date:
-
2020-04-18
Terms of use
- Copyright holder:
- Hell, SM et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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