- Abstract:
-
Gram negative pathogens are protected against toxic electrophilic compounds by glutathione-gated potassium efflux systems (Kef) that modulate cytoplasmic pH. We have elucidated the mechanism of gating through structural and functional analysis of Escherichia coli KefC. The revealed mechanism can explain how subtle chemical differences in glutathione derivatives can produce opposite effects on channel function. Kef channels are regulated by potassium transport and NAD-binding (KTN) domains tha...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1012716107
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 107
- Issue:
- 46
- Pages:
- 19784-19789
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:281e33fc-88af-40ab-8754-2b1d68057643
- Source identifiers:
-
103756
- Local pid:
- pubs:103756
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Mechanism of ligand-gated potassium efflux in bacterial pathogens.
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