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Mechanism of ligand-gated potassium efflux in bacterial pathogens.

Abstract:

Gram negative pathogens are protected against toxic electrophilic compounds by glutathione-gated potassium efflux systems (Kef) that modulate cytoplasmic pH. We have elucidated the mechanism of gating through structural and functional analysis of Escherichia coli KefC. The revealed mechanism can explain how subtle chemical differences in glutathione derivatives can produce opposite effects on channel function. Kef channels are regulated by potassium transport and NAD-binding (KTN) domains tha...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1012716107

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
46
Pages:
19784-19789
Publication date:
2010-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:281e33fc-88af-40ab-8754-2b1d68057643
Source identifiers:
103756
Local pid:
pubs:103756

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