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Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS-CoV-2 in mice

Abstract:

SARS-CoV-2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID-19). The type I interferon (IFN) pathway is of particular importance for anti-viral defense and recent studies identified that type I IFNs drive early inflammatory responses to SARS-CoV-2. Here, we use a mouse model of SARS-CoV-2 infection, facilitating viral entry by intranasal recombinant Adeno-Associated Virus (rAAV) transduction of hACE2 in wildtype (WT) and type I IFN r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.202249913

Authors


Publisher:
Wiley
Journal:
European Journal of Immunology More from this journal
Volume:
52
Issue:
11
Pages:
1768-1775
Place of publication:
Germany
Publication date:
2022-10-07
Acceptance date:
2022-09-13
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
36106692
Language:
English
Keywords:
Pubs id:
1279523
Local pid:
pubs:1279523
Deposit date:
2023-02-04

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