Frequent co-infection among human group a rotaviruses in Thailand.

Journal article

Rotavirus (RoV) is a non-enveloped dsRNA virus in the Reoviridae family, with a 18.5-kb genome of 11 segments encoding six structural (VP1–4, VP6 and VP7) and five or six non-structural proteins (NSP1-NSP5/6). Reassortment between human and/or animal RoVs plays an important role in the generation of genetic diversity in these viruses, and is presumed to result from co-infection in human or animal reservoirs. However, coinfection with heterologous RoV has rarely been documented, in part due to inadequate detection methods and a lack of largescale genomic investigations. Despite the availability of an efficacious vaccine, the burden of rotaviral diarrhea remains high in many developing countries, with rotavirus infection detected in 40–50% of all pediatric patients hospitalized with diarrhea. In addition to its cost, reduced vaccine effectiveness in developing country settings has contributed to its low uptake and the lack of government support for vaccination programs across Southeast Asia. The genetics and dynamics of rotavirus (RoV) have rarely been systematically investigated in these settings.

Authors: Rabaa, M; Dung, T; Duy, P; Bodhidatta, L; Swierczewski, B

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Virus Evolution
• Volume: 3
• Issue: Suppl 1
• Pages: S11
• Publication date: 2017-03-01
• DOI: 10.1093/ve/vew036.027
• EISSN: 2057-1577
• Pmid: 28845279
• Language: English
• Keywords: Journal Article; research-article